880794-92-3Relevant academic research and scientific papers
Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents
Fan, Xuesen,Feng, Dong,Qu, Yingying,Zhang, Xinying,Wang, Jianji,Loiseau, Philippe M.,Andrei, Graciela,Snoeck, Robert,Clercq, Erik De
supporting information; experimental part, p. 809 - 813 (2010/05/18)
A highly practical and efficient preparation of pyrano[3,2-c]pyridone and pyrano[4,3-b]pyran derivatives was developed via an ionic liquid mediated and promoted multi-component reaction of aldehyde (1), 4-hydroxy-pyridin-2(1H)-one or 4-hydroxy-2-pyranone (2), and malononitrile (3). As an application, a series of pyrimidine nucleoside-pyrano[3,2-c]pyridone or pyrano[4,3-b]pyran hybrids were efficiently obtained. These hybrid compounds were evaluated as potential antiviral and antileishmanial agents and showed encouraging biological activities.
