880806-97-3Relevant academic research and scientific papers
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action
Bonardi, Alessandro,Nocentini, Alessio,Bua, Silvia,Combs, Jacob,Lomelino, Carrie,Andring, Jacob,Lucarini, Laura,Sgambellone, Silvia,Masini, Emanuela,McKenna, Robert,Gratteri, Paola,Supuran, Claudiu T.
, p. 7422 - 7444 (2020)
The "tail approach"has become a milestone in human carbonic anhydrase inhibitor (hCAI) design for various therapeutics, including antiglaucoma agents. Besides the classical hydrophobic/hydrophilic division of hCAs active site, several subpockets have been
