880874-67-9Relevant academic research and scientific papers
Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β
Garcia Collazo, Ana-Maria,Koehler, Konrad F.,Garg, Neeraj,Faernegardh, Mathias,Husman, Bolette,Ye, Liu,Ljunggren, Jan,Mellstroem, Karin,Sandberg, Johnny,Grynfarb, Marlena,Ahola, Harri,Malm, Johan
, p. 1240 - 1244 (2007/10/03)
Based on the examination of the crystal structure of rat TRβ complexed with 3,5,3′-triiodo-l-thyronine (2) a novel TRβ-selective indole derivative 6b was prepared and tested in vitro. This compound was found to be 14 times selective for TRβ over TRα in bi
