881005-27-2

Upstream product

• 349398-11-4 methyl N-nosyl-p-aminobenzoate 
• 74-88-4 methyl iodide 
• 619-45-4 4-methoxycarbonyl aniline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 186581-53-3 diazomethane 

Downstream Products

• 881005-28-3 C₁₄H₁₂N₂O₆S 
• 3406-75-5 2-(4-nitrophenylthio)acetic acid 
• 18358-63-9 methyl 4-(N-methyl)aminobenzoate 

Relevant academic research and scientific papers

Inhibitors of Histone Deacetylase

The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the

Highly specific N-monomethylation of primary aromatic amines

A synthetic methodology for the specific conversion of primary aromatic amines into their N-monomethyl derivatives under very mild conditions is presented. Anilines are treated with 4-nitrobenzenesulfonyl (nosyl) chloride to generate the corresponding sulfonamides 2 in high yields. The subsequent N-methylation reaction of the sulfonamides 2 with a solution of diazomethane is rapid and quantitative. Removal of the nosyl protecting group is readily carried out using the reagent system mercaptoacetic acid/1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) affording the N-monomethylated aromatic amines 4. The procedure is convenient, efficient, and gives rise to the N-monomethyl-anilines exclusively.