881006-06-0Relevant articles and documents
Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]- 1H-indoles: Potent and selective aromatase inhibitors
Leze, Marie-Pierre,Le Borgne, Marc,Pinson, Patricia,Palusczak, Anja,Duflos, Muriel,Le Baut, Guillaume,Hartmann, Rolf W.
, p. 1134 - 1137 (2007/10/03)
The synthesis and the aromatase (CYP19) inhibitory activity of 5-[(aryl)(imidazol-1-yl)methyl]-1H-indoles were reported. Among the tested racemate compounds, 5-[(4-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-indole 8b emerged as a potent CYP19 inhibitor (IC