881040-63-7

Usage

Chemical Class

The compound belongs to the class of imidazopyridine derivatives.

Structure

It has a unique structure consisting of a tetrahydronaphthalene ring fused to an imidazopyridine ring system.

Pharmacological Activities

The compound has diverse pharmacological activities, such as antiviral, anticancer, and anti-inflammatory properties.

Serotonin Receptor Antagonist

It can act as a selective serotonin receptor antagonist, making it potentially useful for the treatment of various mental health disorders.

Therapeutic Agent

The compound has been studied for its potential as a therapeutic agent for neurological disorders, such as Parkinson's disease and Alzheimer's disease.

Medical and Pharmaceutical Applications

2-(5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL)IMIDAZO[1,2-A]PYRIDINE holds promise for various medical and pharmaceutical applications due to its chemical and biological properties.

Upstream product

• 504-29-0 2-aminopyridine 
• 5896-66-2 2-bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone 
• 110-86-1 pyridine 
• 1333119-97-3 C₁₄H₁₇NO₂ 

Relevant academic research and scientific papers

Copper-Catalyzed Aerobic Oxidative Cyclization of Ketoxime Acetates with Pyridines for the Synthesis of Imidazo[1,2-a]pyridines

A copper(I)-catalyzed aerobic oxidative coupling of ketoxime acetates with simple pyridines for the synthesis of imidazo[1,2-a]pyridines has been developed. This reaction tolerates a wide range of functional groups and it affords a series of valuable imidazo[1,2-a]pyridines in high yields under mild conditions.

Modulation of carcinogen metabolizing enzymes by new fused heterocycles pendant to 5,6,7,8-tetrahydronaphthalene derivatives

The treatment of 2-bromo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone (1) with pyridine, 2-methylpyridine or 4-methylpyridine afforded their corresponding pyridinum bromides 3a-c. The latter salts reacted with activated acetylene to give the corresponding indolizine derivatives 6a-c. Imidazo[1,2-a]pyridine 9a,b, quinoxaline 15, imidazo[1,2-b][1,2,4]triazole 18 and imidazo[1,2-a]benzimidazole 21 derivatives were prepared from 1 as a starting material. The investigation of the derivative influence on the carcinogen metabolizing enzymes and in the tumor initiation process revealed that 3a-c were strong inducers of epoxide hydrolase (mEH), and that 3a was an inducer of glutathione S-transferases (GSTs) and glutathione (GSH) and a potent scavenger of ROO{radical dot} and OH{radical dot} and inhibited the induced DNA damage, while 3b was a scavenger of ROO{radical dot} and a moderate inhibitor of DNA damage. Additionally, 6a-c significantly induced quinine reductase (QR) activity, whereas 6b induced GSTs, and 6c elevated GSH content, while both of 6b and 6c scavenged OH{radical dot} and inhibited the DNA damage. On the other hand, 9a possessed a moderate scavenging activity of ROO{radical dot} and inhibitory effect on the induced DNA damage, while 18 was a strong inducer of QR activity, scavenger of OH{radical dot}, and inhibitor of the DNA damage and 2 was a significant inhibitor of cytochrome P-450 1A (Cyp1A) and was an inducer of GSTs, and GSH, and a moderate inhibitor of the DNA damage.