88115-32-6Relevant academic research and scientific papers
Retro Aza Diels-Alder Reactions of 2-Azanorbornenes: Improved Methods for the Unmasking of Primary Amines
Grieco, Paul A.,Clark, Jerry D.
, p. 2271 - 2272 (1990)
The unmasking of primary amines via the heterocycloreversion of N-alkyl-2-azanorbornenes can be catalyzed by either copper(II) or a sulfonic acid based ion exchange resin which obviates the necessity of employing a reactive dienophile to trap the cyclopentadiene as it is produced.
Access to Indole-Fused Benzannulated Medium-Sized Rings through a Gold(I)-Catalyzed Cascade Cyclization of Azido-Alkynes
Greiner, Luca C.,Inuki, Shinsuke,Arichi, Norihito,Oishi, Shinya,Suzuki, Rikito,Iwai, Tomohiro,Sawamura, Masaya,Hashmi, A. Stephen K.,Ohno, Hiroaki
, p. 12992 - 12997 (2021/07/20)
Because benzannulated and indole-fused medium-sized rings are found in many bioactive compounds, combining these fragments might lead to unexplored areas of biologically relevant and uncovered chemical space. Herein is shown that α-imino gold carbene chem
Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]-thiazole-5- sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist
Cole, Derek C.,Stock, Joseph R.,Lennox, William J.,Bernotas, Ronald C.,Ellingboe, John W.,Boikess, Steve,Coupet, Joseph,Smith, Deborah L.,Leung, Louis,Zhang, Guo-Ming,Feng, Xidong,Kelly, Michael F.,Galante, Rocco,Huang, Pingzhong,Dawson, Lee A.,Marquis, Karen,Rosenzweig-Lipson, Sharon,Beyer, Chad E.,Schechter, Lee E.
, p. 5535 - 5538 (2008/03/15)
N1-Arylsulfonyltryptamines have been identified as 5-HT 6 receptor ligands. In particular, N1(6-chloroimidazo[2,1- b][1,3]thiazole-5-sulfonyl)tryptamine (11q) is a high affinity, potent full agonist (5-HT6 Ksub
Mannich biscyclizations. Total synthesis of (-)-ajmalicine
L?gers, Michael,Overman, Larry E.,Welmaker, Gregory S.
, p. 9139 - 9150 (2007/10/02)
A concise enantioselective total synthesis of the cardiovascular agent (-)-ajmalicine and an approach toward the synthesis of (+)-19-epiajmalicine are described. The key step of the (-)-ajmalicine synthesis is a carboxylate-terminated N-acyliminium ion biscyclization (74 → 67), which assembles the D and E rings of this heteroyohimbine alkaloid in one step. A related carboxylate-terminated iminium ion biscyclization (28 → 29) is the central step in the approach to (+)-epiajmalicine.
