88121-97-5

Upstream product

• 110-89-4 piperidine 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 116596-42-0 Boc-Asp(piperidide)-OH 
• 24730-33-4 (S)-2-amino-3-phenylpropanamide hydrobromide 
• 13798-75-9 N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester 
• 60058-69-7 (tert-butyloxycarbonyl)-β-benzyl-L-aspartyl-L-phenylalanine amide 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 
• 139033-24-2 Boc-Asp(piperidide)-OPfp 

Relevant academic research and scientific papers

Aspartate Racemization in Synthetic Peptides. Part 2. Tendency to Racemization of Aminosuccinyl Residue

Aminosuccinyl (Asu) peptides, containing a strained ring system, are very vulnerable to epimerization and, during their formation, even as transients, in the presence of nucleophilic and nonnucleophilic bases, partial epimerization occurs.In the presence

Effect of Piperidine on Benzylaspartyl Peptides in Solution and in the Solid Phase

Basic conditions (e.g. piperidinolysis), used for the removal of the Nα-9-fluorenylmethyloxycarbonyl group, lead to significant cleavage of side-chain benzyl esters of peptides containing benzylaspartyl residues both in solution and solid-phase syntheses, the intermediate imide derivative is slowly transformed to a mixture of piperidides.