88126-50-5Relevant academic research and scientific papers
Cytotoxic constituents of the roots of Exostema acuminatum
Ito,Chai,Young Geun Shin,Garcia,Mejia,Gao,Fairchild,Lane,Menendez,Farnsworth,Cordell,Pezzuto,Kinghorn
, p. 6401 - 6405 (2000)
Bioassay-guided phytochemical investigation of the roots of Exostema acuminatum (Rubiaceae) using human oral epidermoid carcinoma (KB) cells as a monitor, led to the isolation of two norditerpenoids, namely, (16R)-ent-16,17-dihydroxy-19-nor-kaur-4-en-3-one (1) and (16S)-ent-16,17-dihydroxy-19-nor-kaur-4-en-3-one (2), and six previously known 4-phenylcoumarins (3-8). The structure and relative stereochemistry of the novel compound 1 were determined by X-ray crystallography. All isolates were tested against a panel of human tumor cell lines, and the 4-phenylcoumarins showed significant cytotoxicity, with 3'-hydroxy-5,7,4'-trimethoxy-4-phenylcoumarin (5) and 8-hydroxy-5,7,4'-trimethoxy-4-phenylcoumarin (6) exhibiting the most potent activity. Two of the 4-phenylcoumarins, 5,7,4'-trimethoxy-4-phenylcoumarin (3) and 6, were evaluated in an in vivo P388 murine leukemia model. (C) 2000 Elsevier Science Ltd.
Synthesis and antiprotozoal activity of 4-arylcoumarins
Pierson, Jean-Thomas,Dumètre, Aurélien,Hutter, Sébastien,Delmas, Florence,Laget, Michèle,Finet, Jean-Pierre,Azas, Nadine,Combes, Sébastien
experimental part, p. 864 - 869 (2010/04/26)
A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium falciparum and Leishmania donovani. Several compounds were found to strongly inhibit the proliferation
Synthesis of neoflavones by Suzuki arylation of 4-substituted coumarins
Boland, Gerard M.,Donnelly, Dervilla M. X.,Finet, Jean-Pierre,Rea, Martin D.
, p. 2591 - 2597 (2007/10/03)
Palladium-catalysed coupling of the 4-chloro- or 4-bromo-coumarins 1-4 with arylboronic acids 5-13 under the Suzuki reaction conditions constitutes an efficient access to 4-arylcoumarins. These 4-arylcoumarins can also be obtained in good yields (70-97%)
SYNTHESIS OF 4-ARYLCOUMARINS FROM COUTAREA HEXANDRA
Monache, Giuliano Delle,Botta, Bruno,Monache, Franco Delle,Botta, Maurizio
, p. 1355 - 1358 (2007/10/02)
Key Word Index - Coutarea hexandra; Rubiaceae; neoflavonoids; 4-arylcoumarins; synthesis. - The structures assigned to the 5,7-dimethoxy-4-arylcoumarins isolated from Coutarea hexandra have been confirmed by synthesis, via Pechmann condensation of phlorog
A Facile Synthesis of 4-Aryl-2H-1-benzopyran-2-ones
Ahluwalia, Vinod K.,Singh, Daljeet,Singh, Rishi P.
, p. 869 - 872 (2007/10/02)
Reaction of 2-hydroxybenzophenones (1, 3, 7, 8) with ethoxycarbonylmethylenetriphenylphosphorane affords 4-aryl-2H-1-benzopyran-2-ones (2, 4-6) in excellent yields. - Keywords: 4-Aryl-2H-1-benzopyran-2-ones; Ethoxycarbonylmethylenetriphenylphosphorane; Friedel-Crafts reaction; 2-Hydroxybenzophenones; Wittig reaction
4-ARYLCOUMARINS FROM COUTAREA HEXANDRA
Monache, Giuliano Delle,Botta, Bruno,Neto, Amaro Serafim,Lima, Roberto Alves De
, p. 1657 - 1658 (2007/10/02)
Four new 4-arylcoumarins have been isolated from Coutarea hexandra and their structures established as 5,7,4'-trimethoxy-4-phenylcoumarin, 4'-hydroxy-5,7-dimethoxy-4-phenylcoumarin, 3'-hydroxy-5,7-4'-trimethoxy-4-phenylcoumarin and 3',4'-dihydroxy-5,7-dimethoxy-4-phenylcoumarin.Key Word Index - Coutarea hexandra; Rubiaceae; neoflavonoids; 4-arylcoumarins.
