881310-04-9

Basic information

• Product Name: (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate
• Synonyms: (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate;(2S)-2-(hydrazinecarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester;(2S)-2-carbazoylpyrrolidine-1-carboxylic acid tert-butyl ester;tert-butyl (2S)-2-(aminocarbamoyl)pyrrolidine-1-carboxylate;tert-butyl (2S)-2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate;tert-butyl(S)-2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate;tert-butyl (2S)-2-(hydrazinocarbonyl)-1-pyrrolidinecarboxylate
• CAS NO: 881310-04-9
• Molecular Formula: C₁₀H₁₉N₃O₃
• Molecular Weight: 229.28
• Mol File: 881310-04-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 395.8±31.0 °C(Predicted)
• Appearance: /
• Density: 1.180±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.86±0.20(Predicted)
• CAS DataBase Reference: (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate(881310-04-9)
• EPA Substance Registry System: (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate(881310-04-9)

Safety Data

• Hazardous Substances Data: 881310-04-9(Hazardous Substances Data)

Usage

General Description

(S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate is a chemical compound with the molecular formula C11H21N3O3. It is a pyrrolidine derivative and contains a hydrazinecarbonyl group. (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and organic molecules. Its (S)-chirality gives it specific stereochemical properties that make it useful for the development of enantiomerically pure compounds. Additionally, its tert-butyl and ester moieties provide stability and protection for the molecule during reactions, making it a valuable reagent in chemical synthesis. Overall, (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate has important applications in drug development and organic chemistry research.

Upstream product

• 122588-88-9 (S)-tert-butyl 2-(2-((benzyloxy)carbonyl)hydrazinecarbonyl)pyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 147-85-3 L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 

Downstream Products

• 881310-14-1 C₂₃H₃₂N₄O₆ 
• 881310-09-4 C₂₇H₃₄N₄O₆ 
• 704898-75-9 N'-benzyl-Boc-L-proline hydrazide 
• 1246168-75-1 C₂₆H₃₉N₅O₇S 
• 1436861-93-6 trans-2-[N'-(6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-hydrazinocarbonyl]-(S)-pyrrolidin-1-carboxylic acid tert-butyl ester 
• 881310-11-8 C₂₃H₃₄N₄O₄ 
• 881310-10-7 C₂₁H₂₇F₃N₄O₅ 

Relevant articles and documents

Synthesis of a new chiral organocatalyst derived from (S)-proline containing a 1,2,4-triazolyl moiety and its application in the asymmetric aldol reaction. Importance of one molecule of water generated in situ

A simple and efficient preparation of a novel chiral derivative of (S)-proline containing a 1,2,4-triazolyl moiety is described. The high-yielding synthetic protocol includes the use of microwave irradiation to afford new chiral pyrrolidine derivatives in

NOVEL -LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME

The currently available β-lactamase inhibitors are insufficient to inhibit the incessantly increasing β-lactamase, and novel β-lactamase inhibitors has been required today for the difficult treatment for bacterial infectious diseases caused by resistant bacteria which produce class C β-lactamase, extended-spectrum β-lactamase (ESBL) belonging to class A and D, or class A KPC-2 decomposing even carbapenem as a last resort for β-lactam antibiotic. A compound represented by the the formula (I), preparation process of the same, β-lactamase inhibitors and method for treating bacterial infectious diseases are provided.

Synthesis of GABAA receptor agonists and evaluation of their α-subunit selectivity and orientation in the GABA binding site

Drugs used to treat various disorders target GABAA receptors. To develop α subunit selective compounds, we synthesized 5-(4-piperidyl)-3-isoxazolol (4-PIOL) derivatives. The 3-isoxazolol moiety was substituted by 1,3,5-oxadiazol-2-one, 1,3,5-oxadiazol-2-thione, and substituted 1,2,4-triazol-3-ol heterocycles with modifications to the basic piperidine substituent as well as substituents without basic nitrogen. Compounds were screened by [3H]muscimol binding and in patch-clamp experiments with heterologously expressed GABAA αiβ 3γ2 receptors (i = 1-6). The effects of 5-aminomethyl-3H-[1,3,4]oxadiazol-2-one 5d were comparable to GABA for all α subunit isoforms. 5-piperidin-4-yl-3H-[1,3,4]oxadiazol-2-one 5a and 5-piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione 6a were weak agonists at α2-, α3-, and α5-containing receptors. When coapplied with GABA, they were antagonistic in α2-, α4-, and α6-containing receptors and potentiated α3-containing receptors. 6a protected GABA binding site cysteine-substitution mutants α1F64C and α1S68C from reacting with methanethiosulfonate-ethylsulfonate. 6a specifically covalently modified the α1R66C thiol, in the GABA binding site, through its oxadiazolethione sulfur. These results demonstrate the feasibility of synthesizing α subtype selective GABA mimetic drugs.