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  • SAGECHEM/tert-butyl (S)-2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate/SAGECHEM/Manufacturer in China

    Cas No: 881310-04-9

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881310-04-9 Usage


(S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate is a pyrrolidine derivative with the molecular formula C11H21N3O3. It is a chiral compound with (S)-configuration and contains a hydrazinecarbonyl group. The presence of a tert-butyl and ester moiety provides stability and protection during chemical reactions, making it a valuable reagent in organic synthesis and medicinal chemistry.


Used in Organic Synthesis:
(S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate is used as a building block for the synthesis of various organic molecules. Its unique structure and functional groups enable the formation of diverse chemical entities, contributing to the development of novel compounds with potential applications in various fields.
Used in Medicinal Chemistry:
In the pharmaceutical industry, (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate is used as a key intermediate for the synthesis of pharmaceuticals. Its (S)-chirality and specific stereochemical properties make it useful for the development of enantiomerically pure compounds, which are essential for ensuring the desired biological activity and minimizing potential side effects.
Used in Drug Development:
(S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate plays a crucial role in drug development, as it can be incorporated into the molecular structure of potential drug candidates. Its versatility and reactivity in chemical reactions allow for the exploration of new chemical space and the optimization of drug-like properties, such as potency, selectivity, and pharmacokinetics.
Overall, (S)-tert-Butyl 2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate is a versatile and valuable compound in the fields of organic synthesis, medicinal chemistry, and drug development. Its unique structural features and reactivity make it an essential building block for the creation of novel and effective molecules with potential applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 881310-04-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,1,3,1 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 881310-04:
149 % 10 = 9
So 881310-04-9 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name tert-butyl (2S)-2-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names <(S)-1-(tert-Butyloxycarbonyl)-2-pyrrolidinoyl>hydrazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:881310-04-9 SDS

881310-04-9Relevant articles and documents

Synthesis of a new chiral organocatalyst derived from (S)-proline containing a 1,2,4-triazolyl moiety and its application in the asymmetric aldol reaction. Importance of one molecule of water generated in situ

Sánchez-Antonio, Omar,Juaristi, Eusebio

, (2019/09/16)

A simple and efficient preparation of a novel chiral derivative of (S)-proline containing a 1,2,4-triazolyl moiety is described. The high-yielding synthetic protocol includes the use of microwave irradiation to afford new chiral pyrrolidine derivatives in



, (2015/04/15)

The currently available β-lactamase inhibitors are insufficient to inhibit the incessantly increasing β-lactamase, and novel β-lactamase inhibitors has been required today for the difficult treatment for bacterial infectious diseases caused by resistant bacteria which produce class C β-lactamase, extended-spectrum β-lactamase (ESBL) belonging to class A and D, or class A KPC-2 decomposing even carbapenem as a last resort for β-lactam antibiotic. A compound represented by the the formula (I), preparation process of the same, β-lactamase inhibitors and method for treating bacterial infectious diseases are provided.

Synthesis of GABAA receptor agonists and evaluation of their α-subunit selectivity and orientation in the GABA binding site

Jansen, Michaela,Rabe, Holger,Strehle, Axelle,Dieler, Sandra,Debus, Fabian,Dannhardt, Gerd,Akabas, Myles H.,Lüddens, Hartmut

supporting information; experimental part, p. 4430 - 4448 (2009/06/06)

Drugs used to treat various disorders target GABAA receptors. To develop α subunit selective compounds, we synthesized 5-(4-piperidyl)-3-isoxazolol (4-PIOL) derivatives. The 3-isoxazolol moiety was substituted by 1,3,5-oxadiazol-2-one, 1,3,5-oxadiazol-2-thione, and substituted 1,2,4-triazol-3-ol heterocycles with modifications to the basic piperidine substituent as well as substituents without basic nitrogen. Compounds were screened by [3H]muscimol binding and in patch-clamp experiments with heterologously expressed GABAA αiβ 3γ2 receptors (i = 1-6). The effects of 5-aminomethyl-3H-[1,3,4]oxadiazol-2-one 5d were comparable to GABA for all α subunit isoforms. 5-piperidin-4-yl-3H-[1,3,4]oxadiazol-2-one 5a and 5-piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione 6a were weak agonists at α2-, α3-, and α5-containing receptors. When coapplied with GABA, they were antagonistic in α2-, α4-, and α6-containing receptors and potentiated α3-containing receptors. 6a protected GABA binding site cysteine-substitution mutants α1F64C and α1S68C from reacting with methanethiosulfonate-ethylsulfonate. 6a specifically covalently modified the α1R66C thiol, in the GABA binding site, through its oxadiazolethione sulfur. These results demonstrate the feasibility of synthesizing α subtype selective GABA mimetic drugs.

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