881381-12-0

Basic information

• Product Name: 2-Formylthiophene-4-boronic acid pinacol ester
• Synonyms: 2-Formylthiophene-4-boronic acid pinacol ester;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Thiophenecarboxaldehyde;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-formylthiophen-3-yl)boronate;4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde
• CAS NO: 881381-12-0
• Molecular Formula: C₁₁H₁₅BO₃S
• Molecular Weight: 238.11
• EINECS: 200-258-5
• Mol File: 881381-12-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Formylthiophene-4-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Formylthiophene-4-boronic acid pinacol ester(881381-12-0)
• EPA Substance Registry System: 2-Formylthiophene-4-boronic acid pinacol ester(881381-12-0)

Safety Data

• Hazardous Substances Data: 881381-12-0(Hazardous Substances Data)

Usage

General Description

2-Formylthiophene-4-boronic acid pinacol ester is a chemical compound with a molecular formula of C12H15BO4S. It is a boronic acid ester derivative of 2-formylthiophene, containing a boron atom attached to the thiophene ring. 2-Formylthiophene-4-boronic acid pinacol ester is commonly used in organic chemistry as a reagent for Suzuki-Miyaura coupling reactions, which is a powerful method for forming carbon-carbon bonds. It is also utilized in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity and stability. Additionally, 2-Formylthiophene-4-boronic acid pinacol ester has potential applications in materials science, particularly in the development of organic electronic devices and sensors. Overall, this compound plays an important role in the field of organic synthesis and has wide-ranging implications in various scientific and industrial applications.

Upstream product

• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 893737-05-8 3-(5-formylthiophen-3-yl)benzonitrile 

Relevant articles and documents

Highly fluorescence emissive 5, 5′-distyryl-3, 3′-bithiophenes: Synthesis, crystal structure, optoelectronic and thermal properties

Seven 5,5′-distyryl-3,3′-bithiophene derivatives (1–7) with A-π-A or D-π-D structures were synthesized and their photophysical, electrochemical, and thermal properties were investigated. Photoluminescence experiments showed that the compounds gave a high fluorescence emission. In photophysical studies, compound 2, which has a nitro substituent, showed significant solvatochromism, thermochromism and aggregation induced emission (AIE) characteristics. Cyclic voltammetry and thermogravimetric analysis indicated that 2 had good electron affinity and thermal stability. The molecular structures and packing arrangements were identified by single crystal X-ray diffraction. Theoretical calculations for the electronic transitions explained the observed special optical behaviors of 2 well. The excellent optical properties of 2 made it a promising emitter for optoelectronics.

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (1): where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds o