881381-12-0

Basic information

• Product Name: 2-Formylthiophene-4-boronic acid pinacol ester
• Synonyms: 2-Formylthiophene-4-boronic acid pinacol ester;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-Thiophenecarboxaldehyde;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-formylthiophen-3-yl)boronate;4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbaldehyde
• CAS NO: 881381-12-0
• Molecular Formula: C₁₁H₁₅BO₃S
• Molecular Weight: 238.11
• EINECS: 200-258-5
• Mol File: 881381-12-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Formylthiophene-4-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Formylthiophene-4-boronic acid pinacol ester(881381-12-0)
• EPA Substance Registry System: 2-Formylthiophene-4-boronic acid pinacol ester(881381-12-0)

Safety Data

• Hazardous Substances Data: 881381-12-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
2-Formylthiophene-4-boronic acid pinacol ester is utilized as a reagent in Suzuki-Miyaura coupling reactions, which are widely recognized for their effectiveness in forming carbon-carbon bonds. This application is crucial for the synthesis of complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-Formylthiophene-4-boronic acid pinacol ester serves as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic benefits.
Used in Materials Science:
2-Formylthiophene-4-boronic acid pinacol ester also finds potential applications in materials science, particularly in the realm of organic electronic devices and sensors. Its properties make it a candidate for components in these advanced technologies, where its reactivity and stability are advantageous.
Overall, 2-Formylthiophene-4-boronic acid pinacol ester is a multifaceted compound with significant implications in scientific and industrial applications, particularly in organic synthesis, pharmaceutical development, and materials science.

Upstream product

• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 893737-05-8 3-(5-formylthiophen-3-yl)benzonitrile 

Relevant articles and documents

Highly fluorescence emissive 5, 5′-distyryl-3, 3′-bithiophenes: Synthesis, crystal structure, optoelectronic and thermal properties

Seven 5,5′-distyryl-3,3′-bithiophene derivatives (1–7) with A-π-A or D-π-D structures were synthesized and their photophysical, electrochemical, and thermal properties were investigated. Photoluminescence experiments showed that the compounds gave a high fluorescence emission. In photophysical studies, compound 2, which has a nitro substituent, showed significant solvatochromism, thermochromism and aggregation induced emission (AIE) characteristics. Cyclic voltammetry and thermogravimetric analysis indicated that 2 had good electron affinity and thermal stability. The molecular structures and packing arrangements were identified by single crystal X-ray diffraction. Theoretical calculations for the electronic transitions explained the observed special optical behaviors of 2 well. The excellent optical properties of 2 made it a promising emitter for optoelectronics.

Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof

The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

INDOLE CARBOXAMIDES AS IKK2 INHIBITORS

The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (1): where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds o