881392-57-0Relevant articles and documents
[PSI[CH2NH]PG4] glycopeptide antibiotic analogs
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Page/Page column Sheet 6, (2008/06/13)
[ψ[CH2NH]PG4] glycopeptide antibiotic analogs are reengineered forms of glycopeptides that exhibit antimicrobial activity against both wild type and glycopeptide antibiotic resistant strains of microorganisms. For example, [ψ[CH
Total synthesis and evaluation of [Ψ[CH2NH]Tpg 4]vancomycin aglycon: Reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding
Crowley, Brendan M.,Boger, Dale L.
, p. 2885 - 2892 (2007/10/03)
An effective synthesis of [Ψ[CH2NH]Tpg4] vancomycin aglycon (5) is detailed in which the residue 4 amide carbonyl of vancomycin aglycon has been replaced with a methylene. This removal of a single atom was conducted to enhance bindin