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881402-05-7

Benzamide, N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-2-thiazolyl]-4-iodo- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 881402-05-7 Structure

  • Basic information

    1. Product Name: Benzamide, N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-2-thiazolyl]-4-iodo-
    2. Synonyms:
    3. CAS NO:881402-05-7
    4. Molecular Formula: C17H9F4IN2OS
    5. Molecular Weight: 492.235
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 881402-05-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Benzamide, N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-2-thiazolyl]-4-iodo-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Benzamide, N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-2-thiazolyl]-4-iodo-(881402-05-7)
    11. EPA Substance Registry System: Benzamide, N-[4-[2-fluoro-3-(trifluoromethyl)phenyl]-2-thiazolyl]-4-iodo-(881402-05-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 881402-05-7(Hazardous Substances Data)

881402-05-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 881402-05-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,1,4,0 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 881402-05:
(8*8)+(7*8)+(6*1)+(5*4)+(4*0)+(3*2)+(2*0)+(1*5)=157
157 % 10 = 7
So 881402-05-7 is a valid CAS Registry Number.

881402-05-7Downstream Products

881402-05-7Relevant articles and documents

Thrombopoietin Receptor Agonists

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Page/Page column 26; 31, (2010/11/30)

A compound of the formula (I) useful as promoters of thrombopoiesis and megakaryocytopoiesis, wherein A, B, D, E, W, X, Y, Z, R1 and R2 are defined as above.

Pyrimidine benzamide-based thrombopoietin receptor agonists

Reiter, Lawrence A.,Subramanyam, Chakrapani,Mangual, Emilio J.,Jones, Christopher S.,Smeets, Marc I.,Brissette, William H.,McCurdy, Sandra P.,Lira, Paul D.,Linde, Robert G.,Li, Qifang,Zhang, Fangning,Antipas, Amy S.,Blumberg, Laura C.,Doty, Jonathan L.,Driscoll, James P.,Munchhof, Michael J.,Ripp, Sharon L.,Shavnya, Andrei,Shepard, Richard M.,Sperger, Diana,Thomasco, Lisa M.,Trevena, Kristen A.,Wolf-Gouveia, Lilli A.,Zhang, Liling

, p. 5447 - 5454 (2008/03/11)

A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation at C-5 of the thiazole, the likely source of toxic metabolites, was removed by substitution at C-5 or by replacing the thiazole with a thiadiazole. Potency in the series was improved by modifying the substituents on the pyrimidine and/or on the thiazole or thiadiazole pendant aryl ring. In vivo examination revealed that compounds from the series are not highly bioavailable. This is attributed to low solubility and poor permeability.

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