88141-37-1

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(1E)-N-hydroxy-3-phenylcyclohex-2-en-1-imine is used as a chemical compound in pharmaceutical research and drug development due to its unique structure and potential biological activity. Its specific properties may contribute to the discovery and creation of new medications.
Used as a Reagent in Organic Synthesis and Chemical Reactions:
In the field of organic chemistry, (1E)-N-hydroxy-3-phenylcyclohex-2-en-1-imine serves as a reagent, facilitating various chemical reactions and synthesis processes. Its reactivity and properties make it a useful tool for chemists working on the development of new organic compounds.
Used in Organic Chemistry Research:
(1E)-N-hydroxy-3-phenylcyclohex-2-en-1-imine is also utilized in organic chemistry research to explore its properties and reactivity. This study can lead to a better understanding of its behavior in chemical reactions and may uncover new applications or reactions involving (1E)-N-hydroxy-3-phenylcyclohex-2-en-1-imine.

Upstream product

• 10345-87-6 3-phenylcyclohex-2-enone 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 504-02-9 1,3-cylohexanedione 
• 3506-36-3 3-dimethylaminopropiophenone 
• 768-03-6 Phenyl vinyl ketone 
• 859936-34-8 2-oxo-4-phenyl-cyclohex-3-enecarboxylic acid ethyl ester 
• 24740-28-1 ethyl 5-phenyl-2-acetyl-5-oxopentanoate 

Downstream Products

• 2113-54-4 N-(biphenyl-3-yl)acetamide 
• 88141-41-7 3-phenylcyclohex-2-enone O-tosyloxime 

Relevant academic research and scientific papers

Synthesis of chiral seven-membered β-substituted lactams: Via Rh-catalyzed asymmetric hydrogenation

Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered β-substituted α,β-unsaturated lactams was successfully developed to prepare various chiral seven-membered β-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).

Pd-catalyzed Semmler-Wolff reactions for the conversion of substituted cyclohexenone oximes to primary anilines

Homogeneous Pd catalysts have been identified for the conversion of cyclohexenone and tetralone O-pivaloyl oximes to the corresponding primary anilines and 1-aminonaphthalenes. This method is inspired by the Semmler-Wolff reaction, a classic method that exhibits limited synthetic utility owing to its forcing conditions, narrow scope, and low product yields. The oxime N-O bond undergoes oxidative addition to Pd0(PCy3)2, and the product of this step has been characterized by X-ray crystallography and shown to undergo dehydrogenation to afford the aniline product.

Synthesis of 3-aryl-6-aminocyclohex-2-enol derivatives

6-(N-Substituted amino)-3-arylcyclohex-2-enol was designed as a new type of β-adrenergic blocker on the basis of the X-ray crystallographic data for propranolol. Eight such compounds were prepared by a six-step sequence of reactions from 3-aryl-cyclohex-2