88142-96-5Relevant academic research and scientific papers
Formation of 2,3-seco-acids in the biotransformation of the diterpene ribenone by Gibberella fujikuroi
Fraga, Braulio M.,Gonzalez, Pedro,Hernandez, Melchor G.,Suarez, Sergio
, p. 1781 - 1792 (1999)
The biotransformation of ribenone (ent-3-oxo-13-epi-manoyl oxide) (4) by the fungus Gibberella fujikuroi led to compounds hydroxylated at C-1(α), C- 6(β), C-11(β) or C-12(β), in addition to the 2,3-seco diacids 15, 17 and 19.
CHEMICAL-MICROBIOLOGICAL SYNTHESIS OF ENT-13-EPI-MANOYL OXIDES WITH BILOGICAL ACTIVITIES
Garcia-Granados, Andres,Jimenez, M Belinda,Martinez, Antonio,Parra, Andres,Rivas, Francisco,Arias, Jose Maria
, p. 741 - 748 (2007/10/02)
The biotransformation of ent-13-epi-3-keto manoyl oxide, which possesses antileishmania activity, with Curvularia lunata produced ent-6β-hydroxy, ent-1α-hydroxy, ent-11β-hydroxy and Δ1-derivatives, as well as a reduction product at C-3 (S-alcohol) with another hydroxyl group at C-6 (ent-6β) or C-11 (ent-11β).The ent-6β-hydroxy and Δ1-derivatives inhibited growth of the pathogenic protozoa, Leishmania donovoni.The biotransformation of ent-12α-hydroxy-3β-hydroxy-13-epi-manoyl oxide and ent-3β-acetoxy-12-oxo-13-epi-manoyl oxide gave the ent-6β-hydroxyl derivatives.The incubation of ent-3β-acetoxy-12β-dihydroxy-13-epi-manoyl oxide gave ent-3β,12β-dihydroxy-13-epi-manoyl oxide and ent-3β,6β,12β-trihydroxy-13-epi-manoyl oxide (trimanoyl).Both products increased the activity of adenylatecyclase. - Key words: Curvularia lunata; biotransformation; ent-13-epi-manoyl oxides; antileishmanic activity; adenylatecyclase activator.
