88149-94-4 Usage
Uses
Used in Pharmaceutical Industry:
DuP-697 is used as a nonsteroidal anti-inflammatory drug (NSAID) for its ability to inhibit COX-2, which plays a significant role in inflammation and pain. By selectively targeting COX-2, DuP-697 can provide anti-inflammatory and analgesic effects with potentially fewer side effects compared to non-selective COX inhibitors.
Used in Inflammation and Pain Management:
DuP-697 is used as an anti-inflammatory and analgesic agent for managing inflammation and pain. Its selective inhibition of COX-2 makes it a potential candidate for treating conditions such as arthritis, where reducing inflammation and pain is crucial for improving patient quality of life.
Used in Research and Development:
DuP-697 is used as a research tool for studying the role of COX-2 in various physiological and pathological processes. Its selective inhibition of COX-2 allows researchers to investigate the specific effects of COX-2 inhibition in different experimental models, contributing to a better understanding of the underlying mechanisms of inflammation and pain.
Biological Activity
Potent and selective inhibitor of cyclooxygenase-2 (IC 50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo . Orally active.
Check Digit Verification of cas no
The CAS Registry Mumber 88149-94-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,1,4 and 9 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 88149-94:
(7*8)+(6*8)+(5*1)+(4*4)+(3*9)+(2*9)+(1*4)=174
174 % 10 = 4
So 88149-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-16(18)22-17(15)12-2-6-13(19)7-3-12/h2-10H,1H3
88149-94-4Relevant academic research and scientific papers
Redox-Divergent Construction of (Dihydro)thiophenes with DMSO
Chen, Qing-An,He, Gu-Cheng,Hu, Yan-Cheng,Ji, Ding-Wei,Liu, Heng,Zhang, Xiang-Xin,Zhao, Chao-Yang
, p. 24284 - 24291 (2021/10/08)
Thiophene-based rings are one of the most widely used building blocks for the synthesis of sulfur-containing molecules. Inspired by the redox diversity of these features in nature, we demonstrate herein a redox-divergent construction of dihydrothiophenes, thiophenes, and bromothiophenes from the respective readily available allylic alcohols, dimethyl sulfoxide (DMSO), and HBr. The redox-divergent selectivity could be manipulated mainly by controlling the dosage of DMSO and HBr. Mechanistic studies suggest that DMSO simultaneously acts as an oxidant and a sulfur donor. The synthetic potentials of the products as platform molecules were also demonstrated by various derivatizations, including the preparation of bioactive and functional molecules.
Divergent synthesis of 2,3,5-substituted thiophenes by C-H activation/borylation/suzuki coupling
Kallepalli, Venkata A.,Sanchez, Luis,Li, Hao,Gesmundo, Nathan J.,Turton, Clarissa L.,Maleczka Jr., Robert E.,Smith III, Milton R.
experimental part, p. 1429 - 1448 (2010/10/20)
C-H activation/borylation has been married with Suzuki coupling to prepare DuP 697 (1) and analogs that would be otherwise difficult to obtain via the traditional synthetic route to 1.
2,3-diaryl-5-bromothiophene compounds of use for the treatment of inflammaton and dysmenorrhea
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, (2008/06/13)
A small group of 2,3-diaryl-5-bromothiophene compounds such as 5-bromo-2-(4-methylthiophenyl)-3-(4-fluorophenyl)thiophene have been found to possess significant and unexpected antiinflammatory activity, and inhibition of prostaglandin synthetase useful fo
