88150-49-6

Upstream product

• 68064-69-7 (Z)-methyl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate 
• 88150-45-2 ethyl 4-(2-azidoethoxy)acetoacetate 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 97813-53-1 2-[2-(5-Carbamoyl-[1,2,3]triazol-1-yl)-ethoxymethyl]-4-(2,3-dichloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 97801-22-4 2-[2-(4-Carbamoyl-[1,2,3]triazol-1-yl)-ethoxymethyl]-4-(2,3-dichloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 97801-19-9 1-<2-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyrid-2-yl>methoxy>ethyl>-5-(ethoxycarbonyl)-1,2,3-triazole 
• 97801-18-8 1-<2-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyrid-2-yl>methoxy>ethyl>-4-(ethoxycarbonyl)-1,2,3-triazole 
• 90444-74-9 4-(2,3-Dichloro-phenyl)-2-methyl-6-(2-[1,2,3]triazol-1-yl-ethoxymethyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-ethyl ester 3-methyl ester 
• 88150-50-9 2-[(2-aminoethoxy)methyl]-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 

Relevant academic research and scientific papers

Dihydropyridine anti-ischaemic and antihypertensive agents

1,4-Dihydropyridine derivatives of the formula: STR1 wherein R is aryl or heteroaryl: R1 and R2 are each independently C1 -C4 alkyl or 2-methoxyethyl; Y is --(CH2)n --, --CH2 CH(CH3)-- or --CH2 C(CH3)2 --; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may optionally be substituted by one or more C1 -C4 alkyl, phenyl, benzyl, CN, --N(R3)2, (CH2)m CO2 H, (CH2)m CO2 (C1 -C4 alkyl) or (CH2)m CON(R3)2 group wherein each R3 is independently H or C1 -C4 alkyl and m is 0 or 1; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.

Dihydropyridine anti-ischaemic and antihypertensive agents

1,4-Dihydropyridine derivatives of the formula: STR1 wherein R is aryl or heteroaryl; R1 and R2 are each independently C1 -C4 alkyl or 2-methoxyethyl; Y is --(CH2)n --, --CH2 CH(CH3)-- or --CH2 C(CH3)2 13 ; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may optionally be substituted by one or more C1 -C4 alkyl, phenyl, benzyl, CN, --N(R3)2, (CH2)m CO2 H, (CH2)m CO2 (C1 -C4 alkyl) or (CH2)m CON(R3)2 group wherein each R3 is independently H or C1 -C4 alkyl and m is 0 or 1; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.