88151-76-2Relevant academic research and scientific papers
Protonation of acyl anion equivalents generated from acylphosphonates: nonhydride access to the aldehyde oxidation state from the carboxylic acid oxidation state
Demir, Ayhan S.,Reis, ?mer,Esiringü, Ilker,Reis, Barbaros,Baris, Sehriban
, p. 160 - 165 (2007/10/03)
Acylphosphonates, which are easily available from carboxylic acids, are potent acyl anion precursors and undergo cyanide ion promoted phosphonate-phosphate rearrangement to provide the corresponding acyl anion equivalents as reactive intermediates. The protonation of these acyl anion equivalents furnished cyanohydrin O-phosphates in good yields. For the high yield formation of cyanohydrin O-phosphates from arylphosphonates THF should be used and from alkylphosphonates DME was used.
Cyano-phosphorylation of aldehydes catalyzed by a nucleophilic N-heterocyclic carbene
Fukuda, Yoshimasa,Maeda, Yuka,Kondo, Kazuhiro,Aoyama, Toyohiko
, p. 397 - 398 (2007/10/03)
The first method for cyano-phosphorylation of aldehydes with diethyl cyanophosphonate in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride and KOt-Bu, as a nucleophilic catalyst, is described.
CYANOPHOSPHORYLATION OF KETONES AND ALDEHYDES USING DIETHYL PHOSPHOROCYANIDATE (DEPC)
Harusawa, Shinya,Yoneda, Ryuji,Kurihara, Takushi,Hamada, Yasumasa,Shioiri, Takayuki
, p. 2932 - 2935 (2007/10/02)
A novel one-pot and high-yield cyanophosphorylation of carbony compounds is achieved by treatment of ketones or aldehydes with diethyl phosphorocyanidate (DEPC) in the presence of a catalytic amount of lithium diisopropylamide in tetrahydrofuran.KEYWORDS
