88156-32-5Relevant academic research and scientific papers
Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution
Tamura, Osamu,Hashimoto, Masaru,Kobayashi, Yuko,Katoh, Tadashi,Nakatani, Kazuhiko,Kamada, Masahiro,Hayakawa, Isao,Akiba, Toshifumi,Terashima, Shiro
, p. 3889 - 3904 (2007/10/02)
The title synthesis was achieved by employing highly cis-selective cyclopropanation of N-benzyl-N-vinylcarbamates with zinc-monofluorocarbenoid, deprotection of the formed N-benzyl-N-(cis-2-fluorocyclopropyl)carbamates, and optical resolution of the resul
13 C shieldings in syn and anti aldimines and ketimines
Fraser, Robert R.,Banville, Jacques,Akiyama, Fuminori,Chuaqui-Offermanns, Noemi
, p. 705 - 709 (2007/10/02)
The 13 C chemical shifts in a variety of aldimines and in both acyclic and cyclic ketimines have been examined.A comparison of the shieldings at the α carbons in syn versus anti stereoisomers shows a consistent upfield shift of 8-11 ppm in the syn isomer.The greater magnitude found in imines vs. oximes or hydrazones is a clear indication of a steric origin for the differential shieldings.The shifts in the imines of cyclohexanones exhibited stereochemically dependent effects of methyl substitution, very similar to those in analogous oxime and hydrazone derivatives.Chemical shift differences in the syn isomers of the α-phenetylimines of chiral aldimines and ketimines allow a facile measurement of diastereomer ratios for such compounds.
