881589-86-2Relevant academic research and scientific papers
Nickel-Catalyzed Cross-Dehydrogenative Coupling of α-C(sp3)-H Bonds in N-Methylamides with C(sp3)-H Bonds in Cyclic Alkanes
Li, Ze-Lin,Sun, Kang-Kang,Cai, Chun
supporting information, p. 6420 - 6424 (2018/10/15)
A nickel-catalyzed cross-dehydrogenative coupling reaction of α-C(sp3)-H bonds in N-methylamides with C(sp3)-H bonds from cyclic alkanes has been developed, which offers a cheap transition-metal-catalyzed C-H activation method for amides without the requirement for any extraneous directing group. This new strategy is highly selective and tolerates a variety of functional groups. Mechanistic investigations into the reaction process are also described in detail.
