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2,3-Diphenyl-5-aminotetrazolium chloride, commonly known as MTT, is a yellow tetrazolium salt that serves as a vital tool in cell viability assays. It is reduced by mitochondrial succinate dehydrogenase in living cells to form insoluble purple formazan crystals, which can be solubilized and quantified to measure the metabolic activity of the cells. This process provides an indication of cell viability, proliferation, and cytotoxicity, making MTT a crucial component in research and pharmaceutical development.

88159-28-8

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88159-28-8 Usage

Uses

Used in Research and Pharmaceutical Development:
2,3-Diphenyl-5-aminotetrazolium chloride is used as a cell viability indicator for assessing the effects of drugs, toxins, and other substances on cell populations. It helps in determining the metabolic activity of cells, which is essential for evaluating the impact of various agents on cell health and survival.
Used in the Development of New Therapeutic Agents:
MTT is used as a tool in the development of new therapeutic agents for various diseases, including cancer and neurodegenerative disorders. By measuring the metabolic activity of cells in response to potential treatments, researchers can gain insights into the efficacy and safety of these agents, guiding the advancement of novel therapies.
Used in Cancer Research:
In cancer research, 2,3-Diphenyl-5-aminotetrazolium chloride is used as a cell viability assay to evaluate the cytotoxic effects of potential anticancer drugs. By assessing the metabolic activity of cancer cells in response to these agents, researchers can determine their potential effectiveness in treating various types of cancer.
Used in Neurodegenerative Disorder Research:
MTT is also used in neurodegenerative disorder research as a cell viability assay to study the impact of potential therapeutic agents on neuronal cells. This helps in understanding the protective or detrimental effects of these agents on neuronal health and function, contributing to the development of treatments for conditions such as Alzheimer's and Parkinson's diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 88159-28-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,1,5 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 88159-28:
(7*8)+(6*8)+(5*1)+(4*5)+(3*9)+(2*2)+(1*8)=168
168 % 10 = 8
So 88159-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H12N5.ClH/c14-13-15-17(11-7-3-1-4-8-11)18(16-13)12-9-5-2-6-10-12;/h1-10H,(H2,14,15,16);1H/q+1;/p-1

88159-28-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3-Diphenyl-5-aminotetrazolium Chloride

1.2 Other means of identification

Product number -
Other names 5-Amino-2,3-diphenyl-2H-tetrazolium chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:88159-28-8 SDS

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