881652-47-7Relevant academic research and scientific papers
Synthesis of Sultams and Cyclic N-Sulfonyl Ketimines via Iron-Catalyzed Intramolecular Aliphatic C-H Amidation
Zhong, Dayou,Wu, Di,Zhang, Yan,Lu, Zhiwu,Usman, Muhammad,Liu, Wei,Lu, Xiuqiang,Liu, Wen-Bo
, p. 5808 - 5812 (2019/08/26)
Cyclic sulfonamides (sultams) play a unique role in drug discovery and synthetic chemistry. A direct synthesis of sultams by an intramolecular C(sp3)-H amidation reaction using an iron complex in situ derived from Fe(ClO4)2 and aminopyridine ligand is reported. This strategy features a readily available catalyst and tolerates a broad variety of substrates as demonstrated by 22 examples (up to 89% yield). A one-pot iron-catalyzed amidation/oxidation procedure for the synthesis of cyclic N-sulfonyl ketimines is also realized with up to 92% yield (eight examples). The synthetic utility of the method is validated by a gram-scale reaction and derivatization of the products to ring-fused sultams.
Sultam compound and preparation method thereof
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Paragraph 0167-0172, (2019/11/12)
The invention provides a sultam compound and a preparation method thereof. The method provided by the invention specifically comprises the following steps: putting a catalyst C, sulfamide B and an oxidant D into an organic solvent, performing a reaction,
Formal palladium-catalyzed asymmetric hydrogenolysis of racemic N -sulfonyloxaziridines
Song, Bo,Yu, Chang-Bin,Huang, Wen-Xue,Chen, Mu-Wang,Zhou, Yong-Gui
supporting information, p. 190 - 193 (2015/01/30)
Highly enantioselective palladium-catalyzed formal hydrogenolysis of racemic N-sulfonyloxaziridines has been realized, providing a novel access to sultams with up to 99% ee. Preliminary mechanistic insights revealed that the reaction proceeded through a N-O bond cleavage, dehydration, and the sequential asymmetric hydrogenation.
A synthesis of novel N-sulfonylated β-amino acids
Freitag, Dirk,Metz, Peter
, p. 1799 - 1805 (2007/10/03)
Novel N-sulfonyl β-amino acids were efficiently prepared in a seven-step synthesis starting from Boc protected methanesulfonamide and terminal epoxides. A zinc-mediated allylation of cyclic N-sulfonyl imines readily derived from these building blocks serv
