881672-84-0Relevant academic research and scientific papers
Ultrasound accelerated synthesis of novel benzimidazole derived chalcones as glucosidases inhibitor and antimicrobial agents
Meshram, Gangadhar A,Vala, Vipul A.,Wagh, Pramod A.,Deshpande, Shruti S.
, p. 613 - 623 (2017/01/18)
A novel series of 3-substituted-1-[1-(toluene-4-sulfonyl)-1H-benzoimidazol-2-yl]-propen-1-one 3a-m have been synthesized by tosylation of benzimidazole chalcones 2a-m using ultrasound in lesser time with higher yields. All the synthesized compounds have been characterized by IR, 1H and 13C NMR, mass and elemental analysis in full accordance with their depicted structure. Biological evaluation of the compounds 3a-m reveals that compound 3f shows moderate inhibition of glucoamylase and compound 3i exhibits compelling inhibition of α-amylase. Compound 3k and 3d display excellent antibacterial activity against all tested strains and admirable antifungal activity against Candida albicans respectively in comparison to the standards. The results of biological study show that introduction of tosyl group in benzimidazole chalcones enhances the inhibition of glycosidases and microorganism in comparison to parent compounds.
Solid phase synthesis of benzimidazole ketones and benzimidazole chalcones under solvent-free conditions
Dubey,Kumar, C. Ravi,Babu, Balaji
, p. 3128 - 3130 (2007/10/03)
Oxidation of 1-alkyl/aralkyl-2-(α-hydroxyalkyl/aryl)benzimidazoles 1 with KMnO4 on neutral alumina under solid phase conditions gives the corresponding ketones, 1-alkyl/aralkyl-2-acyl-benzimidazoles 2. Compound 2a (R2 = CH3) on condensation with aromatic aldehydes in the presence of solid NaOH under solvent-free conditions, yields the corresponding chalcones, 1-alkyl/aralkyl-2-benzimidazole aryl vinyl ketone 3.
Synthesis of some 1-(2-arylvinyl)-3-arylpyrazino[1,2-a]benzimidazole derivatives and their antimicrobial activities
Demirayak,Abu Mohsen,Chevallet,Erdeniz,Kiraz
, p. 825 - 827 (2007/10/03)
Some 1-(2-arylvinyl)-3-arylhyrazino[1,2-a]benzimidazole derivatives were synthesized, their structures were elucidated, and their antibacterial and antifungal activities were examined. None of the compounds proved to be sufficiently active.
