881840-75-1Relevant academic research and scientific papers
Constructing Mononuclear Palladium Catalysts by Precoordination/Solvothermal Polymerization: Recyclable Catalyst for Regioselective Oxidative Heck Reactions
Li, Wen-Hao,Li, Cun-Yao,Xiong, Huan-Yan,Liu, Yang,Huang, Wen-Yong,Ji, Guang-Jun,Jiang, Zheng,Tang, Hai-Tao,Pan, Ying-Ming,Ding, Yun-Jie
supporting information, p. 2448 - 2453 (2019/02/03)
Heterogeneous, metal, single-site catalysts often exhibit higher catalytic performance than other catalysts because of their maximized atom efficiency of 100 %. Reported herein is a precoordination/solvothermal polymerization strategy to fabricate a stabl
Intramolecular cyclopropanation of unsaturated terminal epoxides and chlorohydrins
Hodgson, David M.,Ying, Kit Chung,Nuzzo, Irene,Freixas, Gloria,Kulikiewicz, Krystyna K.,Cleator, Ed,Paris, Jean-Marc
, p. 4456 - 4462 (2008/02/02)
Lithium 2,2,6,6-tetramethylpiperidide (LTMP)-induced intramolecular cyclopropanation of unsaturated terminal epoxides provides an efficient and completely stereoselective entry to bicyclo[3.1.0]hexan-2-ols and bicyclo[4.1.0]heptan-2-ols. Further elaboration of C-5 and C-6 stannyl-substituted bicyclo[3.1.0]-hexan-2-ols via Sn-Li exchange/electrophile trapping or Stille coupling generates a range of substituted bicyclic cyclopropanes. An alternative straightforward cyclopropanation protocol using a catalytic amount of 2,2,6,6-tetramethylpiperidine (TMP) allows for a convenient (1 g-7.5 kg) synthesis of bicyclo[3.1.0]-hexan-2-ol and other bicyclic adducts. The synthetic utility of this chemistry has been demonstrated in a concise asymmetric synthesis of (+)-β-cuparenone. The related unsaturated chlorohydrins also undergo intramolecular cyclopropanation via in situ epoxide formation.
Intramolecular cyclopropanation of unsaturated terminal aziridines
Hodgson, David M.,Humphreys, Philip G.,Ward, John G.
, p. 995 - 998 (2007/10/03)
Regio- and stereoselective deprotonation of bishomoallylic terminal N-Bus (Bus = tert-butylsulfonyl)-protected aziridines generate aziridinyl anions that undergo diastereoselective Intramolecular cyclopropanation giving trans-2-aminobicyclo[3.1.0]hexanes in good to excellent yields.
