881850-41-5Relevant academic research and scientific papers
Branched diacylglycerol-lactones as potent protein kinase C ligands and α-secretase activators
Lee, Jeewoo,Kang, Ji-Hye,Han, Kee-Chung,Kim, Yerim,Kim, Su Yeon,Youn, Hae-Suk,Mook-Jung, Inhee,Kim, Hee,Han, Jee Hye Lo,Ha, Hee Jin,Kim, Young Ho,Marquez, Victor E.,Lewin, Nancy E.,Pearce, Larry V.,Lundberg, Daniel J.,Blumberg, Peter M.
, p. 2028 - 2036 (2007/10/03)
Using as our lead structure a potent PKC ligand (1) that we had previously described, we investigated a series of branched DAG-lactones to optimize the scaffold for PKC binding affinity and reduced lipophilicity, and we examined the potential utility of s
