882004-55-9Relevant academic research and scientific papers
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors
Vlahakis, Jason Z.,Kinobe, Robert T.,Bowers, Raymond J.,Brien, James F.,Nakatsu, Kanji,Szarek, Walter A.
, p. 4437 - 4441 (2006)
Several imidazole-dioxolane compounds were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds, which include (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1, 3-dioxolane (1) hydrochloride, are
HEME-OXYGENASE INHIBITORS AND USE OF THE SAME IN THE TREATMENT OF CANCER AND DISEASES OF THE CENTRAL NERVOUS SYSTEM
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, (2009/01/24)
Disclosed are compounds of the general formula (1): compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods useful for treating or preventing cancer and for inhibiting tumour tissue growth. These compounds attenuate the oxidative damage associated with increased heme-oxygenase activity and can reduce cell proliferation in transformed cells. In addition, the described compounds and compositions are useful as neuroprotectants and for treating or preventing neurodegenerative disorders and other diseases of the central nervous system.
