88203-22-9Relevant academic research and scientific papers
Rapid synthesis of 2,5-disubtituted 1,3,4-thiadiazoles under microwave irradiation
Lebrini, Mounim,Bentiss, Fouad,Lagrenee, Michel
, p. 991 - 994 (2007/10/03)
The one pot, three-components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3,5-disubstituted 1,3,4-thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in-situ. The structure of the compounds was confirmed by 1H, 13C NMR, MS and elemental analysis.
A New Synthesis of Symmetrical 2,5-Diaryl-1,3,4-thiadiazoles
Mazzone, Gioacchino,Puglisi, Giovanni,Bonina, Francesco,Corsaro, Antonino
, p. 1399 - 1401 (2007/10/02)
Treatment of aromatic aldehydes with sulfur and hydrazine hydrate in the ratio 1:2:3, respectively, under the Willgerodt conditions affords the title compounds in excellent yields and in a good state of purity.Under the same conditions 2-chloro and 2,6-dichlorobenzaldehyde yield 3H-1,2-benzodithiole-3-thione and bis(2,6-dichlorobenzyl)tetrasulfide, respectively.
