88203-23-0

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 94-30-4 ethyl 4-methoxybenzoate 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 17453-03-1 2,5-Bis-<4-methoxy-phenyl>-1,3,4-thiadiazol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 83070-65-9 4-hydroxyphenylthiocarboxyhydrazide 
• 17144-00-2 carboxymethyl p-hydroxybenzdithiocarboxylate 

Downstream Products

• 850663-14-8 (R,R)-4,4'-(1,3,4-thiadiazol-2,5-ylen) di(phenoxy-2-propionic acid) 

Relevant academic research and scientific papers

Synthesis, liquid-crystalline, photophysical and chemosensor properties of oxadiazole/thiadiazole-based amphiphiles with glycerol groups

Two series of heterocycle-based mesogens consisting of a long 2,5-diphenyl-1,3,4-oxadiazole/thiadiazole rigid core with three lipophilic and flexible alkyl chains at one end and a polar glycerol group at the opposite end have been synthesized via one pot cyclization reaction. These compounds were investigated by polarizing optical microscopy (POM), differential scanning calorimetry (DSC), X-ray scattering, cyclic voltammetry, UV–vis spectroscopy and photoluminescence measurements. Upon elongation of the alkyl chains, a transition from hexagonal columnar phase to Pm3ˉn-type cubic phase was observed in both series. Oxadiazole series are blue luminescent LCs with binding selectivity to Li+, while thiadiazole series are blue-green luminescent LCs with binding selectivity to Fe3+.

Rapid synthesis of 2,5-disubtituted 1,3,4-thiadiazoles under microwave irradiation

The one pot, three-components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3,5-disubstituted 1,3,4-thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in-situ. The structure of the compounds was confirmed by 1H, 13C NMR, MS and elemental analysis.

A New Synthesis of Symmetrical 2,5-Diaryl-1,3,4-thiadiazoles

Treatment of aromatic aldehydes with sulfur and hydrazine hydrate in the ratio 1:2:3, respectively, under the Willgerodt conditions affords the title compounds in excellent yields and in a good state of purity.Under the same conditions 2-chloro and 2,6-dichlorobenzaldehyde yield 3H-1,2-benzodithiole-3-thione and bis(2,6-dichlorobenzyl)tetrasulfide, respectively.