88205-07-6Relevant academic research and scientific papers
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
Henry, Sean,Kidner, Ria,Reisenauer, Mary R.,Magedov, Igor V.,Kiss, Robert,Mathieu, Véronique,Lefranc, Florence,Dasari, Ramesh,Evidente, Antonio,Yu, Xiaojie,Ma, Xiuye,Pertsemlidis, Alexander,Cencic, Regina,Pelletier, Jerry,Cavazos, David A.,Brenner, Andrew J.,Aksenov, Alexander V.,Rogelj, Snezna,Kornienko, Alexander,Frolova, Liliya V.
, p. 313 - 328 (2016/06/01)
Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanthridin
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: A new paradigm for molecular assembly
Baxendale, Ian R.,Deeley, Jon,Griffiths-Jones, Charlotte M.,Ley, Steven V.,Saaby, Steen,Tranmer, Geoffrey K.
, p. 2566 - 2568 (2008/03/27)
A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, cat
The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines
Saaby, Steen,Knudsen, Kristian Rahbek,Ladlow, Mark,Ley, Steven V.
, p. 2909 - 2911 (2007/10/03)
Imines have been reduced to amines in high yield, and with excellent chemoselectivity, by catalytic hydrogenation in a continuous flow-reactor, utilising an electrochemically-generated hydrogen source to produce a mixed hydrogen-liquid flow stream. The Royal Society of Chemistry 2005.
A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase
Han, Sun-Young,Kitahata, Nobutaka,Saito, Tamio,Kobayashi, Masatomo,Shinozaki, Kazuo,Yoshida, Shigeo,Asami, Tadao
, p. 3033 - 3036 (2007/10/03)
9-cis-Epoxycarotenoid dioxygenase (NCED), a key enzyme in abscisic acid (ABA) biosynthesis, cleaves the olefinic double bond of 9-cis-epoxycarotenoid. Several analogues of nordihydroguaiaretic acid (NDGA) were designed and synthesized, and their efficacy
Synthesis of Amaryllidaceae alkaloids, siculine, oxocrinine, epicrinine, and buflavine
Kodama, Sumiaki,Takita, Hirofumi,Kajimoto, Tetsuya,Nishide, Kiyoharu,Node, Manabu
, p. 4901 - 4907 (2007/10/03)
Three crinane type of alkaloids isolated from Amaryllidaceae family were synthesized by taking advantage of the PIFA-mediated intramolecular p-p′ diphenol coupling reaction of norbelladine derivatives. Furthermore, buflavine was also prepared by using the p-p′ diphenol coupling followed by dienone-phenol rearrangement as a key step.
Synthesis of the alkaloids (±)-oxomaritidine and (±)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents
Ley, Steven V.,Schucht, Olivier,Thomas, Andrew W.,Murray, P. John
, p. 1251 - 1252 (2007/10/03)
The concise synthesis of the alkaloids (±)-oxomaritidine 1 and (±)-epimaritidine 2 in high yield are described, which employs a sequence of five- and six-step reactions respectively, using solely polymer supported reagents in an orchestrated successive ma
