882053-93-2Relevant academic research and scientific papers
Synthesis of 3,4-disubstituted piperidines by carbonyl ene and prins cyclizations: Switching between kinetic and thermodynamic control with Bronsted and Lewis acid catalysts
Williams, Jodi T.,Bahia, Perdip S.,Kariuki, Benson M.,Spencer, Neil,Philp, Douglas,Snaith, John S.
, p. 2460 - 2471 (2006)
A novel approach to cis and trans 3,4-disubstituted piperidines is described. Carbonyl ene cyclization of aldehydes 4a-e catalyzed by MeAlCl 2 in refluxing chloroform afforded the trans piperidines 7a-e with diastereomeric ratios of up to 93:7,
