882055-20-1

Basic information

• Product Name: 7-(4-Fluoro-phenyl)-2-thiophen-3-yl-benzothiazole
• CAS NO: 882055-20-1
• Molecular Weight: 311.404
• Mol File: 882055-20-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(4-Fluoro-phenyl)-2-thiophen-3-yl-benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-Fluoro-phenyl)-2-thiophen-3-yl-benzothiazole(882055-20-1)
• EPA Substance Registry System: 7-(4-Fluoro-phenyl)-2-thiophen-3-yl-benzothiazole(882055-20-1)

Safety Data

• Hazardous Substances Data: 882055-20-1(Hazardous Substances Data)

Upstream product

• 6165-69-1 Thien-3-ylboronic acid 
• 882055-21-2 2-Bromo-7-(4-fluoro-phenyl)-benzothiazole 
• 882055-19-8 7-(4-fluoro-phenyl)-benzothiazole 
• 767-70-4 7-bromo-1,3-benzothiazole 

Downstream Products

• 882055-02-9 4-[7-(4-Fluoro-phenyl)-benzothiazol-2-yl]-thiophene-2-sulfonic acid amide 
• 882055-27-8 4-[7-(4-Fluoro-phenyl)-benzothiazol-2-yl]-thiophene-2-sulfonic acid 
• 882055-39-2 4-[7-(4-Fluoro-phenyl)-benzothiazol-2-yl]-thiophene-2-sulfonyl chloride 

Relevant articles and documents

Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)- thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors

4-(1,3-Benzothiazol-2-yl)thiophene-2-sulfonamide (4a) was found to be a moderately potent inhibitor of cyclin-dependent kinase 5 (cdk5) from a HTS screen. The synthesis and SAR around this hit is described. The X-ray coordinates of ligand 4a with cdk5 are also reported, showing an unusual binding mode to the hinge region via a water molecule.