88220-94-4Relevant academic research and scientific papers
Heterocyclic Tautomerism. IX. Structural Revision of a Series of Pharmacologically Active Pyridazines
Guard, James A. M.,Steel, Peter J.
, p. 1601 - 1608 (2007/10/03)
On the basis of 1H n.m.r. n.O.e. measurements and X-ray crystal structure determination, it is shown that a large series of pharmacologically active pyridazine derivatives should be represented as aromatic pyridazine tautomers , rather than the previously reported arylidene-4,5-dihydropyridazines .Crystals of (7b) are monoclinic P21/c, a 13.312(3), b 7.269(1), c 11.753(2) Angstroem, β 101.38(3) deg, Z = 4; the structure was refined to a conventional R 2?(I)> 0.037.
New 4,5 (3H)dihydro-4-acetyl-2-furanones derivatives: Chemical and pharmacological study
Couquelet,Taoufik,Couquelet,et al.
, p. 301 - 305 (2007/10/02)
5-substituted 4,5 (3H)-dihydro 4-acetyl 2-furanones were synthetized by reaction of aromatic heteroaromatic or cyclanic aldehydes with α-angelicalactone in presence of boron trifluoride. We showed from NMR spectroscopic data that the reaction course was s
