88225-99-4

Upstream product

• 89174-85-6 1-Benzyl-4-hydroxy-3-methyl-4,5-diphenyl-imidazolidin-2-one 
• 1341164-94-0 1-benzyl-3-methyl-4,5-diphenyl-1H-imidazol-3-ium iodide 
• 7346-22-7 1-benzyl-4,5-diphenyl-1H-imidazole 
• 1188338-39-7 1-methyl-3-benzyl-4,5-diphenylimidazolium bromide 
• 88225-95-0 N',N'-dibenzyl-N-methyl-N-thiobenzoylurea 
• 77771-64-3 N-benzyldesylamine 
• 88225-98-3 1-benzyl-4,5-diphenyl-4-mercapto-3-methylimidazolidin-2-one 

Relevant academic research and scientific papers

Metal-free C(sp2)-H functionalization of azoles: K2CO3/I2-mediated oxidation, imination, and amination

The direct C2-H oxidation and imination of a wide variety of azoles was achieved by using a commercially available simple K2CO3/I2 reagent combination. The iodinated azole adduct, produced via the in situ generation of N-heterocyclic carbene, is the key intermediate for C2-H oxidation, imination, and amination of azoles. Significantly, these reactions proceed under mild conditions with high to excellent yields, are scalable to large quantity and exhibit a broad substrate scope. Interestingly, this direct C2-H imination method allowed us to access various pharmacologically active N6-alkyl or N6-aryl substituted benzimidazoquinazolinone scaffolds through intramolecular C-H imination in a sequential one-pot reaction.

Synthesis of 2-imidazolones and 2-iminoimidazoles

Convenient methods for the direct conversion of imidazolium salts to the corresponding 2-imidazolone or 2-imino imidazole derivatives have been developed. Treatment of the salt with commercial bleach leads to effective oxidation at C2 and the formation of the corresponding imidazolone. Alternatively, treatment of the salt with an N-chloro amide affords the corresponding protected 2-amino derivative in good yield.

PHOTOCHEMICAL REACTIONS OF N-THIOAROYLUREAS AND N-THIOAROYLTHIOUREAS

Irradiation of N-thioaroylureas and N-thioaroylthioureas gave imidazolidinones and imidazolidinethiones, respectively both via intramolecular hydrogen abstraction by the thioaroyl groups; the photoproducts were easily converted to the imidazolones and imi

PHOTOCHEMICAL REACTIONS OF N',N'-DIALKYL-N-aroylureas

N',N'-Dibenzyl and N',N'-diisopropyl-N-aroylureas undergo cyclization on irradiation to give the corresponding imidazolidin-2-ones via intramolecular hydrogen abstraction by the aroyl carbonyl group.