882280-89-9Relevant academic research and scientific papers
Discovery of a new class of protein farnesyltransferase inhibitors in the arylthiophene series
Lethu, Sébastien,Ginisty, Maryon,Bosc, Damien,Dubois, Jo?lle
supporting information; experimental part, p. 6205 - 6208 (2010/03/24)
Screening of the ICSN chemical library led to the discovery of 3-(4-chlorophenyl)-4-cyano-5-thioalkylthiophene 2-carboxylic acids as potent farnesyltransferase inhibitors. Enzymatic kinetic studies showed that this original FTI series belongs to the CaaX
