882500-21-2

Basic information

• Product Name: 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine
• Synonyms: 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine;5-bromo-6-(trifluoromethyl)pyridin-2-amine;6-Amino-3-bromo-2-(trifluoromethyl)pyridine;2-Amino-5-bromo-6-(trifluoromethyl)pyridine;2-Pyridinamine,5-bromo-6-(trifluoromethyl)-
• CAS NO: 882500-21-2
• Molecular Formula: C₆H₄BrF₃N₂
• Molecular Weight: 241.02
• Mol File: 882500-21-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 218℃
• Flash Point: 86℃
• Appearance: /
• Density: 1.790
• Refractive Index: 1.524
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.04±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine(882500-21-2)
• EPA Substance Registry System: 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine(882500-21-2)

Safety Data

• Hazardous Substances Data: 882500-21-2(Hazardous Substances Data)

Usage

General Description

5-Bromo-6-trifluoromethyl-pyridin-2-ylamine is a chemical compound with the formula C6H3BrF3N2. It is an aminopyridine derivative that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine has a bromine atom and a trifluoromethyl group attached to a pyridine ring, which makes it a useful intermediate in the production of various functional molecules. It is also known to exhibit antimicrobial and antifungal properties, which makes it an important component in the development of new drugs and agricultural products. Additionally, 5-Bromo-6-trifluoromethyl-pyridin-2-ylamine is used in the development of dyes and pigments due to its unique structural properties.

InChI:InChI=1/C6H4BrF3N2/c7-3-1-2-4(11)12-5(3)6(8,9)10/h1-2H,(H2,11,12)

Upstream product

• 34486-24-3 2-amino-6-(trifluoromethyl)pyridine 

Downstream Products

• 1233243-98-5 6-amino-2-trifluoromethylnicotinonitrile 
• 1256818-23-1 5-phenyl-6-(trifluoromethyl)-2-pyridinamine 
• 1227502-92-2 3-bromo-6-fluoro-2-(trifluoromethyl)pyridine 
• 1628185-65-8 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridin-2-amine 

Relevant articles and documents

CYANOTRIAZOLE COMPOUNDS AND USES THEREOF

The present invention provides a compound of Formula (I), or a pharmaceutically acceptable salt thereof: (I) wherein R1, R2, R3, and R4 are as defined herein. The present invention further provides therapeutic uses of these compounds, for example against human African typanosomiasis; pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL

The present invention relates to pharmaceutical compounds of the Formula (I), or a pharmaceutically acceptable salt or composition thereof, and methods of their use for the treatment of pain, respiratory conditions, as well as inhibiting the Transient Receptor Potential Al ion channel (TRPA1).

Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity

We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P1 agonist 5 to modulate physicochemical properties and optimize in vitro and in vivo activity. The diaza-analog 1