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88257-46-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 88257-46-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,2,5 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 88257-46:
169 % 10 = 9
So 88257-46-9 is a valid CAS Registry Number.

88257-46-9Downstream Products

88257-46-9Relevant articles and documents

Acylsilane chemistry. Synthesis of regio- and stereoisomerically defined enol silyl ethers using acylsilanes

Reich, Hans J.,Holtan, Ronald C.,Bolm, Carsten

, p. 5609 - 5617 (1990)

The preparation of enol silyl ethers using a carbonyl addition-Brook rearrangement-elimination sequence was studied. The key intermediate α-silyl-β-X-alkoxides could be prepared in several different ways, including the addition of organolithium or hydride reagents to α-X-acylsilanes (path a, using RM with R = alkyl, aryl, vinyl, alkynyl, silyl, stannyl, phosphinyl, and cyano), the addition of α-X-lithium reagents to acylsilanes (path b, X = phenylthio, phenylsulfonyl), or the addition of silyllithium reagents to α-X-ketones (path c, X = phenylthio, alkoxy). All of the reactions gave complete regiocontrol of silyl enol ether formation, and many gave excellent (>99%) stereocontrol as well. The selectivity of the carbonyl addition, silyl rearrangement, and elimination was studied. For path a, when the R group of RM was a poor carbanion stabilizing group the elimination of the intermediate α-silyl-β-X-alkoxides was stereospecific, and there was a large difference in rate between erythro and threo (erythro > threo). When R was a carbanion stabilizing group, such as aryl or alkynyl, the elimination process became nonstereospecific in some cases, and only small differences between threo and erythro were observed. Path b was especially effective with α-sulfonyl lithium reagents, and these reactions gave predominantly E enol silyl ethers (4/1 to 20/1). The addition of organolithium reagents to β-X-acylsilanes (the homologue of path a) was also briefly explored as a synthesis of siloxy-cyclopropanes.

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