882697-80-5Relevant academic research and scientific papers
PROCESS FOR PRODUCTION OF (4,5-DIHYDROISOXAZOL-3-YL)THIO- CARBOXAMIDINE SALTS
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, (2008/06/13)
To provide a method for producing a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound simply, safely and in good yield, whereby drawbacks of prior art have been solved. A method for producing a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound of the formula (2): wherein each of R1 and R2 which are independent of each other, is a hydrogen atom, an alkyl group or a cycloalkyl group, each of R3 and R4 which are independent of each other, is a hydrogen atom or an alkyl group, provided that R1 and R2, or R2 and R3, may be bonded to each other to form a cycloalkyl group together with the carbon atoms to which they are bonded, and X2 is a halogen or an anionic residue derived from an acid, which comprises reacting a 3-halogeno-4,5-dihydroisoxazole compound of the formula (1) : wherein R1, R2, R3 and R4 are as defined above, and X1 is a halogen, with thiourea in the presence of an acid.
