88270-40-0Relevant academic research and scientific papers
Utilization of fluoroform for difluoromethylation in continuous flow: A concise synthesis of α-difluoromethyl-amino acids
K?ckinger, Manuel,Ciaglia, Tanja,Bersier, Michael,Hanselmann, Paul,Gutmann, Bernhard,Kappe, C. Oliver
supporting information, p. 108 - 112 (2018/01/12)
Fluoroform (CHF3) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity of fluoroform, only very few applications have been reported so far. Herein we report a continuous flow difluoromethyl
Asymmetric Synthesis of α-Substituted Amino Acids and Amines by Carbon-Carbon Bond Formation in Position α to the Nitrogen
Kolb, Michael,Barth, Jacqueline
, p. 1668 - 1688 (2007/10/02)
The asymmetric synthesis of α-substituted α-amino acids and propargylamines is described.As chiral auxiliary we used (S)-(-)-1-dimethoxymethyl-2-methoxymethylpyrrolidine (SDMP, 1).Treatment of the amino acids or amines with SDMP 1 afforded the correspondi
