88277-23-0Relevant academic research and scientific papers
Total synthesis of optically active m-phenylene PGl2 derivative: Beraprost
Wakita, Hisanori,Yoshiwara, Hideo,Nishiyama, Hisao,Nagase, Hiroshi
, p. 1085 - 1110 (2007/10/03)
The optical isomers of m-phenylene PGl2 derivative, Beraprost, were synthesized in practical scales from optically active carboxy- cyclopenta[b]benzofurans (12 and 13) by Wittig and Wadsworth reactions as key reactions via the intermediate diols (16a and 16b).
Synthesis of (+)-5,6,7-trinor-4,8-inter-m-phenylene PGI2
Nagase, Hiroshi,Matsumoto, Kazuhisa,Yoshiwara, Hideo,Tajima, Atsuko,Ohno, Kiyotaka
, p. 4493 - 4494 (2007/10/02)
The titled compound, which is a stable and potent analog of prostacyclin, was synthesized from readily available 1,4-dibromocyclopentene via cyclopenta[b]benzofuran carboxylic acid 5.
