882812-35-3

Upstream product

• 85-44-9 phthalic anhydride 
• 99-57-0 2-hydroxy-5-nitroaniline 

Downstream Products

• 1289485-90-0 N-(2-(benzyloxy)-5-nitrophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methanesulfonamide 
• 1289486-01-6 N-(2-(benzyloxy)-5-nitrophenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide 
• 1289486-10-7 2-(benzyloxy)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)-5-nitroaniline 
• 88964-90-3 2-amino-4-nitrophenyl benzyl ether 
• 1289485-56-8 C₂₁H₁₄N₂O₅ 

Relevant academic research and scientific papers

Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase

Cyclooxygenase-1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) are enzymes in two different pathways in the inflammatory process. In the present study, a variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes. Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor. Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.