882855-95-0

Basic information

• Product Name: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE
• Synonyms: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE
• CAS NO: 882855-95-0
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.06
• Product Categories: Aromatic Building Blocks
• Mol File: 882855-95-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 345.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.573±0.06 g/cm3(Predicted)
• PKA: 2.89±0.10(Predicted)
• CAS DataBase Reference: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE(882855-95-0)
• EPA Substance Registry System: (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE(882855-95-0)

Safety Data

• Hazardous Substances Data: 882855-95-0(Hazardous Substances Data)

Usage

General Description

(2-AMINO-5-BROMO-PHENYL)-ACETONITRILE is a chemical compound with the molecular formula C8H6BrN2. It consists of a five-membered aromatic ring with a bromine atom and an amino group attached, as well as a nitrile group. (2-AMINO-5-BROMO-PHENYL)-ACETONITRILE has potential applications in the pharmaceutical and agrochemical industries, as it can be used as a building block in the synthesis of various biologically active compounds. Its bromo and amino functional groups make it a valuable intermediate for the preparation of novel heterocyclic compounds and pharmaceuticals. Additionally, it may also have use as an intermediate in the production of dyes and other organic compounds.

Upstream product

• 586-78-7 para-nitrophenyl bromide 
• 125914-22-9 2-(5-bromo-2-nitrophenyl)acetonitrile 
• 610-66-2 2-nitro-benzeneacetonitrile 
• 2973-50-4 2-aminophenylacetonitrile 

Downstream Products

• 1378862-87-3 4-amino-3-cyanomethylbenzonitrile 
• 201227-39-6 5-bromo-1H-indazole-3-carbonitrile 
• 851530-48-8 5-bromo-2-(4-methoxyphenyl)-1H-indole 
• 881040-30-8 5-bromo-2-(4-chlorophenyl)-1H-indole 
• 76609-17-1 5-bromo-2-(4-fluorophenyl)-1H-indole 
• 83515-06-4 5-bromo-2-phenylindole 
• 1190319-99-3 methyl 3-cyano-1H-indazole-5-carboxylate 
• 89671-79-4 (5-bromo-1H-indol-2-yl)(4-bromophenyl)methanone 

Relevant articles and documents

Modular Synthesis of Polysubstituted Quinolin-3-amines by Oxidative Cyclization of 2-(2-Isocyanophenyl)acetonitriles with Organoboron Reagents

Polysubstituted quinolin-3-amines are vital structural motifs because of their broad biological activities as well as versatile transformational abilities. However, they are not easily accessible. We disclose a protocol with Mn(III) acetate as a mild one-

Method for synthesizing indole derivative

The invention relates to a method for synthesizing an indole derivative shown in the formula (III) (please see the specification). The method includes the steps that in a solvent and inertia gas atmosphere, when a catalyst, a nitrogen-containing ligand, an acid accelerator and KF exist, a compound in the formula (I) (please see the specification) and a compound in the formula (II) (please see the specification) are reacted, aftertreatment is carried out after the reaction is completed, and therefore the compound in the formula (III) is obtained, wherein R1 is selected from H or halogen, and R2 is selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogen. According to the method, as a proper substrate, the proper catalyst, the proper nitrogen-containing ligand, the proper acid accelerator, the proper KF, the proper solvent and the like are comprehensively selected and cooperated, the range of the substrate is expanded accordingly, the indole derivative can be obtained with the good yield, the method has good application prospects and research value in the field of organic chemistry synthesis, and a brand new method is provided for synthesis of the compound.

N2-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal.