882999-04-4Relevant articles and documents
Peri-substituted hexahydro-indolones as novel, potent and selective human EP3 receptor antagonists
O'Connell, Matthew,Zeller, Wayne,Burgeson, James,Mishra, Rama K.,Ramirez, Jose,Kiselyov, Alex S.,Andresson, Thorkell,Gurney, Mark E.,Singh, Jasbir
scheme or table, p. 778 - 782 (2009/08/15)
A series of peri-substituted [4.3.0] bicyclic non-aromatic heterocycles have been identified as potent and selective hEP3 receptor antagonists. These molecules adopt a hair-pin conformation that overlaps with the endogenous ligand PGE2/su
