88304-24-9

Upstream product

• 123-38-6 propionaldehyde 
• 100-46-9 benzylamine 

Downstream Products

• 188302-40-1 Benzyl-(1-ethyl-but-3-enyl)-amine 
• 159117-50-7 N-benzyl-N-[(1E)-prop-1-en-1-yl]acetamide 
• 1429044-40-5 2-benzyl-4-methyl-2,8-diazaspiro[4.5]decan-1-one hydrochloride 
• 1429044-11-0 2-benzyl-4-methy1-oxo-2,8-diaza-spiro[4.5]deca-3,6,9-triene-8-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 1429044-04-1 2-benzyl-4-isopropyl-1-oxo-2,8-diaza-spiro[4.5]deca-3,6,9-triene-8-carboxylic acid methyl ester 
• 1429043-85-5 2-benzyl-4-methyl-1-oxo-2,8-diaza-spiro [4.5] deca-3,6,9-triene-8-carboxylic acid trifluoro-methyl ester 
• 1429173-12-5 2-benzyl-4-methyl-2,8-diazaspiro[4.5]decan-1-one 
• 1429043-98-0 1-benzyl-4-methyl-1’-(trifluoromethane)sulfonyl-1,2-dihyro-1’H-spiro[pyrrole-3,4’-quinoline]-2-one 
• 1429043-82-2 (E)-2-benzyl-1-quinolin-4-yl-pent-3-en-1-one 
• 1429043-74-2 N-benzyl-N-((E)-propenyl)-isonicotinamide 

Relevant academic research and scientific papers

Synthesis of 1,5-dihydro-2H-pyrrol-2-ones from an alkyne, an imine and carbon dioxide via an organotitanium intermediate

Azatitanacyclopentene complexes 2 react with carbon dioxide under atmospheric pressure to afford 1,5-dihydro-2H pyrrol-2-ones, thus providing a one-pot procedure for synthesizing a variety of 1,5-dihydro-2H-pyrrol-2-ones from an alkyne, an imine and carbo

Spirocyclic dihydropyridines by electrophile-induced dearomatizing cyclization of N-alkenyl pyridinecarboxamides

On treatment with acylating or sulfonylating agents, N-alkenyl pyridine carboxamides (N-pyridinecarbonyl enamines) undergo a dearomatizing cyclization initiated by pyridine acylation and followed by intramolecular trapping of the resulting pyridinium cation. The products are spirocyclic dihydropyridines which may be further elaborated to spirocyclic heterocycles with drug-like features.

HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS

Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists o

Some reactions of ammonia and primary amines with propanal, 2-chloroethanal, 2,2-dichloroethanal and 2,2,2-trichloroethanal in acetonitrile

The reaction of ammonia with propanal in acetonitrile produces the hexahydrotriazine, 1, in good yield. The corresponding reaction of chloroethanal yields the cyclic trimer 16 but only in poor yield. Increasing chloro-substitution in the aldehyde stabilises the initially formed carbinolamines and disfavours trimerisation. Imines formed by reaction of primary amines with the aldehydes are relatively stable. Those formed from aliphatic amines may undergo slow dimerisation by C-C bond formation and this may be accompanied by loss of amine to yield products containing a conjugated double-bond system. Kinetic and equilibrium data are reported for both the forward and reverse reactions involving interconversion of propanal and ammonia with 1 in acetonitrile-water mixtures. The results indicate that dehydration of the carbinolamine is rate determining.