883085-45-8Relevant academic research and scientific papers
N-heterocyclic carbene-catalyzed oxidation of unactivated aldehydes to esters
Maki, Brooks E.,Scheldt, Karl A.
, p. 4331 - 4334 (2008)
(Chemical Equation Presented) N-Heterocyclic carbenes catalyze the oxidation of unactivated aldehydes to esters with manganese(IV) oxide in excellent yield. The reaction proceeds through a transient activated alcohol, which when generated in situ allows for the selective oxidation of the aldehyde under mild conditions. These conditions successfully oxidize potentially epimerizable aldehydes and alcohols while preserving stereochemical integrity. A variety of ester derivatives can be synthesized with variation of the acylated alcohol as well as the unactivated aldehyde.
Boron/zinc exchange for the conjugate arylation of unsaturated Meldrum's acid derivatives
Jardim, Micaela,Baldassari, Lucas L.,Contreira, Maria Eduarda,Moro, Angélica V.,Lüdtke, Diogo S.
supporting information, (2020/01/31)
An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the β-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as β,β-disubstituted carboxylic acids and amides.
