88312-90-7

Upstream product

• 583-68-6 2-bromo-p-toluidine 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 

Downstream Products

• 88312-91-8 2-amino-N-(2-bromo-4-methylphenyl)benzenesulfonamide 
• 88312-93-0 2-methyl-12-phenyl-5H-dibenzo<1,2,6>thiadiazocin 6,6-dioxide 
• 88312-92-9 2-(2-bromo-4-methylphenyl)-3-phenyl-2H-1,2,4-benzothiadiazin 1,1-dioxide 
• 88312-94-1 2-amino-N-(2-benzoyl-4-methylphenyl)benzenesulfonamide 
• 132749-65-6 N-(4-methyl-2-bromophenyl)-2-(acetylamino)benzenesulfonamide 
• 132749-74-7 N-(4-methyl-2-bromophenyl)-N-methyl-2-(acetylamino)benzenesulfonamide 

Relevant academic research and scientific papers

New Dibenzothiadiazepine derivatives with antidepressant activities

A new series of 11-[(aminoalkyl)carbonyl] derivatives of 6,11-dihydrodibenzo[c,f][1,2,5]thiadiazepine 5,5-dioxide (10-39) were synthesized and evaluated for potential antidepressant activity in the apomorphine-induced hypothermia (Apo 16) test. Effects on reserpine-induced hypothermia and toxicity for the most potent antagonists of Apo 16 hypothermia were also studied. Structure-activity relationships are reported. Anticholinergic effects were evaluated for compound 12, identified as the most potent and least toxic in this series, by assessing physostigmine lethality. Compound 12 was also subjected to X-ray analysis.

HETEROCYCLIC SYNTHESES VIA CARBANIONICALLY INDUCED REARRANGEMENT REACTIONS

The easily occuring -migrations of sulfonyl and carbonyl functions to neighboring phenyl anions can be utilized for ring expansions by one benzo unit when suitably tailored precursor heterocycles are used.Thus, the 1,2- benzisothiazol dioxide systems 8 and 17 can be transformed into dibenzothiazepin dioxides 12 and 21, respectively, whereas the dibenzo- and 1,2,4-benzothiazin dioxide models 35 and 46 give rise to the tribenzothiazocin dioxide and dibenzothiadiazocin dioxide systems 38 and 47, respectively.Unexpected formations of heterocyclic systems, namely, spirobenzoxazin-5,1'(3H)-isobenzofuran> 55, 3,1-benzoxazin 62, and phenanthridinium-salt 70 took place when phtalimide 52, dibenzoylaniline 56, and biphenylylbenzamide 65 were reacted with t-BuLi.