883221-33-8Relevant academic research and scientific papers
Atroposelective Synthesis of Axially Chiral Biaryls by Palladium-Catalyzed Asymmetric C?H Olefination Enabled by a Transient Chiral Auxiliary
Yao, Qi-Jun,Zhang, Shuo,Zhan, Bei-Bei,Shi, Bing-Feng
supporting information, p. 6617 - 6621 (2017/05/29)
Atroposelective synthesis of axially chiral biaryls by palladium-catalyzed C?H olefination, using tert-leucine as an inexpensive, catalytic, and transient chiral auxiliary, has been realized. This strategy provides a highly efficient and straightforward access to a broad range of enantioenriched biaryls in good yields (up to 98 %) with excellent enantioselectivities (95 to >99 % ee). Kinetic resolution of trisubstituted biaryls bearing sterically more demanding substituents is also operative, thus furnishing the optically active olefinated products with excellent selectivity (95 to >99 % ee, s-factor up to 600).
Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones
Moleele, Simon S.,Michael, Joseph P.,De Koning, Charles B.
, p. 2831 - 2844 (2007/10/03)
α-Tetralones were initially converted into 1-bromo- dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2-carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes.
