883236-91-7Relevant articles and documents
Synthesis and biological evaluation of B-ring analogues of (-)-rhazinilam
Decor, Anne,Monse, Barbara,Martin, Marie-Therese,Chiaroni, Angele,Thoret, Sylviane,Guenard, Daniel,Gueritte, Francoise,Baudoin, Olivier
, p. 2314 - 2332 (2006)
Three macrocyclic analogues of rhazinilam 1 having a 11- or 12-membered B-ring with an endocyclic carbamate group or an amino-acid residue were synthesized from the natural product. These analogues 3 and 4 displayed a very low activity on tubulin. Thirty