88324-34-9Relevant academic research and scientific papers
2-Acetylpyridine thiosemicarbazones. 7. Derivatives of 2-acetylquinoline as potential antimalarial agents
Klayman,Scovill,Bartosevich,et al.
, p. 49 - 53 (2007/10/02)
A series of 2-acetylquinoline thiosemicarbazones with potential antimalarial properties was prepared by the reaction of methyl hydrazinecarbodithioate with 2-acetylquinoline to afford methyl 3-[1-(2-quinolyl)ethylidene]hydrazinecarbodithioate (II). Displacement of the S-methyl group of the latter compound by amines gave the desired 2-acetylquinoline thiosemicarbazones (III). Related thiosemicarbazides were obtained by reduction of the azomethine group of II with sodium borohydride to give methyl 3-[1-(2-quinolyl)ethyl]hydrazinecarbodithioate (IV). The S-methyl group of IV was displaced by amines resulting in the formation of 1-[1-(2-quinolyl)ethyl]thiosemicarbazides (V). Evaluation of the antimalarial activity of compound types III and V, performed in mice infected with Plasmodium berghei, showed that most of the test compounds effected cures in the dose range of 320-640 mg/kg.
