88329-16-2

Basic information

• Product Name: 4-(sec-butyl)-N,N-dimethylaniline
• CAS NO: 88329-16-2
• Molecular Weight: 177.29
• Mol File: 88329-16-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(sec-butyl)-N,N-dimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(sec-butyl)-N,N-dimethylaniline(88329-16-2)
• EPA Substance Registry System: 4-(sec-butyl)-N,N-dimethylaniline(88329-16-2)

Safety Data

• Hazardous Substances Data: 88329-16-2(Hazardous Substances Data)

Upstream product

• 403-46-3 4-fluoro-N,N-dimethylaniline 
• 15366-08-2 s-butylmagnesium chloride 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 142509-27-1 5-(1-methylpropyl)-1-aza-5-stannabicyclo[3.3.3]undecane 
• 30273-11-1 4-sec-butylaniline 

Relevant articles and documents

Thorpe–Ingold Effect in Branch-Selective Alkylation of Unactivated Aryl Fluorides

Presented herein is a general protocol for the alkylation of simple aryl fluorides with unbiased secondary Grignard reagents by means of nickel catalysis. This study revealed a general Thorpe–Ingold effect in the ligand backbone which confers a high degree of selectivity for the secondary carbon center in the C?C coupling event. This protocol is characterized by mild reaction conditions, robustness, and simplicity. Both electron-rich and electron-deficient aryl fluorides are suitable candidates in this transformation. Equally amenable are a variety of heterocycles, permitting the coupling without over alkylation at the electrophilic sites.