883312-00-3Relevant academic research and scientific papers
Biotransformation of cycloartane-type triterpenes by the fungus Glomerella fusarioides
Akihisa, Toshihiro,Watanabe, Kenji,Yoneima, Risa,Suzuki, Takashi,Kimura, Yumiko
, p. 604 - 607 (2008/09/20)
Biotransformation of three cycloartane-type triterpenes, cycloartenol (1), 24-methylenecycloartanol (2), and cycloartenone (3), by the fungus Glomerella fusarioides was studied. Compound 1 was converted to 3, cycloart-25-ene-3β, 24-diol (4), and cycloartane-3β,24,25-triol (5). Compound 2 was metabolized to cycloeucalenol (6) and two new compounds, 24-methylcycloartane-3β,24, 241-triol (7) and 241-methoxy-24-methylcycloartane- 3β,24-diol (8). Compound 3 was converted into two new metabolites, 4α,4β,14α-trimethyl-9β,19-cyclopregnane-3,20-dione (9) and 25-hydroxy-24-methoxycycloartan-3-one (14), and four known compounds, viz., cycloartane-3,24-dione (10), 24-hydroxycycloart-25-en-3-one (11), (23E)-25-hydroxycycloart-23-en-3-one (12), and 24,25-dihydroxycycloartan-3-one (13). The structures of four new metabolites, 7, 8, 9, and 14, were established by spectroscopic methods.
Microwave assisted acetylation and deacetylation studies on the triterpenes isolated from Dysoxylum malabaricum and Dysoxylum beddomei
Jayakumar,Ajithabai,Santhosh,Veena,Nairt, Mangalam S.
, p. 429 - 431 (2007/10/03)
Phytochemical investigations on the leaves of Dysoxylum malabaricum and Dysoxylum beddomei result in the isolation of a number of triterpenes. Acetylation and deacetylation studies on some of the representative triterpenes show appreciable rate enhancement and increase of yield in the presence of microwave radiation. Details of isolation of triterpenes, acetylation and deacetylation procedures and their results form the subject of the paper. Triterpenes of three skeletal types namely lupane, tirucallane and cycloartane are examined. All the triterpenes examined indicate an increase of cytotoxicity with acetylation.
